A Syndrome Resembling Adrenal Cortical Insufficiency Associated with Long Term Busulfan (Myleran) Therapy

Four patients who developed a clinical syndrome characterized by hyperpigmentation of the skin, weakness, fatigue, weight loss, anorexia and nausea while on long-term treatment with busulfan were described. The etiology of the disorder, although clearly related to the busulfan therapy, is obscure, but may be related to "dethiolation".