The effect of leurocristine (vincristine) on cell division was studied in normal bone marrow and leukemic cells (L1210 leukemia) of DBA/2 mice. It was found that vincristine possesses the ability to arrest mitosis at the metaphase stage. The accumulation of arrested metaphases in the normal bone marrow and in leukemic cells of the animals treated with vincristine followed a pattern similar to the one observed after treatment with colchicine or vincaleukoblastine (vinblastine).

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© 1963 by American Society of Hematology, Inc.
1963
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