Sickle Cell Anemia with Two Adult Hemoglobins—Hb S and Hb G_Philadelphia/S

Hemoglobin studies have been presented on a patient with clinically typical sickle cell anemia who was found to possess two major adult hemoglobins, Hb S and hybrid Hb G_Phil./S. Four hemoglobins were demonstrated in his mother, Hb A, G_Phil., S and G_Phil./S, in somewhat unexpected and as yet unexplained proportions. To our knowledge the propositus represents the first description of an individual with a homozygous β chain defect accompanied by a heterozygous α chain abnormality.