Abstract
A new method has been described for measuring fibrinolytic activity. The method is based on the change in turbidity resulting from the dissolution of suspended particles of fibrin under the influence of fibrinolytic agents. Because the technic exposes a vast surface area of substrate, measurable changes occur rapidly. The procedure is not complex, yet provides more accurate estimates than other methods employing fibrin as a substrate.
The method also has the advantage that conditions such as temperature, pH and length of incubation can be varied. Experiments illustrating this have been reported.
The following two fibrinolytic agents were studied.
1. Human plasmin activated with glycerin.
2. An extract of Aspergillus oryzae.
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© 1964 by American Society of Hematology, Inc.
1964
