Editorial: Lymphocytopenia in Hodgkin’s Disease

The lymphocytopenia of Hodgkin’s disease has been reviewed in the light of recent knowledge of lymphocyte function. It is suggested that the anergy of early Hodgkin’s disease is a peripheral defect—a manifestation of abnormal lymphocyte function. Later in the course of the condition profound lymphocytopenia develops and most probably contributes to the more severe immunologic deficiencies of advanced Hodgkin’s disease.