Comparison of Hematologic and Febrile Response to Endotoxin in Man

The infusion of endotoxin in man is followed by a fall in mononuclear cell count and subsequent granulocytosis. Significant granulocytopenia was not observed, nor were changes in plasma fibrinogen levels or platelet counts noted. Although a correlation was demonstrated between dose of endotoxin administered and hematologic response, there was no correlation between the magnitude of fever and hematologic changes. Hematologic responsiveness was unchanged following the development of febrile tolerance to endotoxin.