1. An electrophoretically fast hemoglobin was found in approximately 40 per cent of preschool children with elevated blood lead levels.

2. Fast hemoglobin was found more often in lead-poisoned patients with hypochromic anemia than in patients with normochromic red cells.

3. Fast hemoglobin differed from hemoglobins produced in vitro by incubation with chromate or oxidized glutathione. It had electrophoretic properties similar to that found in a few patients receiving tolbutamide.

4. Fast hemoglobin could not be differentiated from normal hemoglobin A3 by any technic utilized.

5. Both lead and A3 hemoglobins were heterogeneous molecular species.

6. The mechanisms leading to the production of hemoglobin A3 and lead hemoglobin remain unknown.

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© 1966 by American Society of Hematology, Inc.
1966
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