An increase in hepatic δ-aminolevulinic acid synthetase is demonstrated in a patient with cutaneous porphyria induced by stilbestrol. A genetically determined increase in this rate-limiting enzyme appears to be the basic abnormality in all of the hepatic porphyrias.

Topics:
diethylstilbestrol, ligase, porphyrias, enzymes, hepatic porphyria
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© 1966 by American Society of Hematology, Inc.
1966
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