In Vitro Development of Bone Marrows from Patients with Neutropenia

Bone marrows from patients with neutropenia, characterized morphologically by a paucity of mature neutrophils, underwent normal maturation when removed from the body and grown in tissue culture. In addition, certain leukopenic plasmas appeared to stimulate development of normal bone marrows under similar circumstances. These observations suggest that the granulocytic elements in benign forms of neutropenia are innately capable of normal sequential growth and that sustained peripheral neutropenia may distort the normal feedback mechanism which regulates leukopoiesis.