Mice inoculated with Rauscher leukemogenic virus, following a series of weekly injections of complete Freund’s adjuvant in combination with virus-unrelated antigens, showed increased survivals and delayed appearances of circulating nucleated erythrocytes characteristic of the leukemia. Virus-neutralizing serum antibody was not observed to be produced as a result of this hyperimmunization. The retardation of leukemogenesis was attributed to a transient diminution of numbers of host target cells available to viral infection as a consequence of their prior commitment along immunologic pathways.

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© 1967 by American Society of Hematology, Inc.
1967
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