The Pattern of Platelet Disappearance

In pigs and in dogs simultaneous tagging of platelets with cohort and population labels suggests that platelet destruction is largely independent of platelet age. No evidence of endogenous platelet aging has been encountered. The implications of these findings are discussed. It seems reasonable for the time being to use the "exponential half-life" as an index of platelet survival without committing oneself to the view that the exponential model adequately represents the phenomenon.