Red Cell Hypoplasia, Cold Hemoglobinuria and M-Type Gamma G Serum Paraprotein and Bence Jones Proteinuria in a Patient With Lymphoproliferative Disorder

This paper documents an unusual example of hypoplastic anemia, intermittent hemoglobinuria appearing in cold weather, and lymphoproliferative disease associated with hypogammaglobulinemia and repeated infections, followed by the appearance of a monoclonal gammopathy (IgG-Kappa) and Bence Jones proteinuria (Kappa), with tissue lesions more characteristic of macroglobulinemia than of multiple myeloma, in a middle-aged Negro.