The Effect of Etiocholanolone on The Entry of Granulocytes into The Peripheral Blood

The influence of etiocholanolone on normal granulocyte kinetics was studied in a group of hematologically normal individuals using H³TdR for cell labeling. Following the establishment of the baseline peripheral blood leukokinetic pattern in each individual, a second study was performed in which etiocholanolone was administered at varying times in relation to H³TdR. No influence upon the peripheral leukocyte kinetic patterns was detected when etiocholanolone was given prior to 74 hours. When given at that time, an accelerated release of labeled granulocytes from the bone marrow was produced. The degree of acceleration appeared to be related to the size of bone marrow granulocyte reserves.