A 52-year-old Caucasian was hospitalized for recurring jaundice. Laboratory tests established a compensated hemolytic anemia due to partial erythrocyte G-6-PD deficiency. Biochemical characterization of the affected enzyme uncovered a unique variant: G-6-PD Tripler. Its significant properties include marked thermal instability, an electrophoretic mobility slower than the normal B variant in all systems studied, and slightly increased affinity for the substrate G-6-P.

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© 1970 by American Society of Hematology, Inc.
1970
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