Localized leukocyte mobilization into autologous serum consists almost entirely of normal appearing granulocytes in normal subjects as well as in patients with acute myelocytic (AML) and acute lymphocytic leukemia (ALL). Sharp reduction in mobilization and in clearance of granulocytes was seen in patients with untreated AML, independent of morphologic subclass, whereas this was not found in ALL. Recombination experiments with leukemic and nonleukemic sera did not reproduce or correct the defects in AML. Nearly normal mobilization and clearance occurred in the remission state. These data taken together suggest that mature granulocytes in florid AML may be mature leukemic cells.

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© 1971 by American Society of Hematology, Inc.
1971
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