Abstract
The third known case of IgE multiple myeloma is described. The patient was a 65-yr-old woman who died 11 mo after a diagnosis of multiple myeloma was made by a surgical biopsy of the left iliac crest. Her serum contained approximately 2.7 g/100 ml of a paraprotein of mid-γ mobility. The isolated anomalous protein gave a reaction of identity with the IgE myeloma protein of the second reported case when reacted with a specific IgE antiserum. The light-chain type of the myeloma protein was κ in contrast to λ of the other two IgE myeloma proteins. Her clinical manifestations differed from the two previously reported cases in several respects. She had neither plasma cell leukemia nor overt Bence Jones proteinuria and developed rapidly progressive widespread osteosclerotic lesions that were associated with bone pain.
