Possible Thrombosthenin Defect in Glanzmann’s Thrombasthenia

Microquantitation of thrombosthenin by single radial immunodiffusion in conjunction with a specific immunohistochemical antibody staining technique has indicated an immunologic defect or absence of the surface-localized thrombosthenin (S-thrombosthenin) in platelets from Glanzmann’s thrombasthenic patients. In addition, ADP- and ATP-induced changes of the surface of normal platelets could not be demonstrated with Glanzmann’s thrombasthenic platelets.