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Article| August 1, 1974

Evidence for a Physiologic Role of Erythropoietin in Fetal Erythropoiesis

Esmail D. Zanjani, Ph.D,

Esmail D. Zanjani, Ph.D

1Departments of Physiology and Medicine, Mount Sinai School of Medicine of the City University of New York, New York, N.Y. 10029; Department of Obstetrics and Gynecology, Nassau County Medical Center and Health Sciences Center, Stony Brook, N.Y. 11790; and Department of Biology, New York University, New York, N.Y. 10003.

2Department of Physiology (Hematology). Mount Sinai School of Medicine of the City University of New York, Fifth A venue and 100th Street. New York. N. Y. 10029.

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Leon I. Mann,

Leon I. Mann

1Departments of Physiology and Medicine, Mount Sinai School of Medicine of the City University of New York, New York, N.Y. 10029; Department of Obstetrics and Gynecology, Nassau County Medical Center and Health Sciences Center, Stony Brook, N.Y. 11790; and Department of Biology, New York University, New York, N.Y. 10003.

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Harold Burlington,

Harold Burlington

1Departments of Physiology and Medicine, Mount Sinai School of Medicine of the City University of New York, New York, N.Y. 10029; Department of Obstetrics and Gynecology, Nassau County Medical Center and Health Sciences Center, Stony Brook, N.Y. 11790; and Department of Biology, New York University, New York, N.Y. 10003.

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Albert S. Gordon,

Albert S. Gordon

1Departments of Physiology and Medicine, Mount Sinai School of Medicine of the City University of New York, New York, N.Y. 10029; Department of Obstetrics and Gynecology, Nassau County Medical Center and Health Sciences Center, Stony Brook, N.Y. 11790; and Department of Biology, New York University, New York, N.Y. 10003.

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Louis R. Wasserman

Louis R. Wasserman

1Departments of Physiology and Medicine, Mount Sinai School of Medicine of the City University of New York, New York, N.Y. 10029; Department of Obstetrics and Gynecology, Nassau County Medical Center and Health Sciences Center, Stony Brook, N.Y. 11790; and Department of Biology, New York University, New York, N.Y. 10003.

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Blood (1974) 44 (2): 285–290.

https://doi.org/10.1182/blood.V44.2.285.285

Abstract

Administration of antibody prepared in rabbits against human urinary Ep to fetal sheep during the last third of the gestation period resulted in a suppression of erythropoiesis in the fetus. This was evidenced by a sharp decrease in the numbers of circulating reticulocytes and a reduced rate of ⁵⁹Fe incorporation into RBC, spleen, and bone marrow, effects ascribable to a neutralization of endogenous Ep. In addition, there was a significant decrease in the numbers of nucleated erythroid cells in the bone marrows of these fetuses. These results point to a physiologic role for Ep in fetal erythropoiesis.

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© 1974 by American Society of Hematology, Inc.

1974

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