The functional integrity of blood and skin Sezary cells was examined in regard to motility, capping proficiency, and intramembranous particle (IMP) mobility. In contrast with chronic lymphocytic leukemia lymphocytes, which are relatively inert in these respects, variable proportions of Sezary cells are motile and are able to cap and cluster their IMP's. Since these functions may reflect a cell's propensity for diapedesis, these observations may help to explain the inverse relationship between the size of the skin infiltrate and the number of circulating Sezary cells often observed in this condition.

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Copyright © 1979 by The American Society of Hematology
1979
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