Monoclonal plasma cell proliferation with secretion of IgA-lambda and free lambda light chains during a phase of bone marrow aplasia following intensive chemotherapy was observed in a patient suffering from acute myelomonoblastic leukemia. The clonal expansion and regression was investigated at the cellular level by immunofluorescence using an antiserum against the idiotype of the paraportein. Although a large panel of common antigens was used for testing, no antibody activity of the paraprotein could be demonstrated.

Topics:
immunoglobulin a, leukemia, paraproteinemias, antibodies, antigens, chemotherapy regimen, immune sera, paraproteins, fluorescent antibody technique, immunoglobulin idiotypes
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Copyright © 1980 by The American Society of Hematology
1980
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