White blood cells from 22 patients with leukemia and lymphoma were studied for the presence of terminal deoxynucleotidyl transferase with a peroxidase-antiperoxidase method. The enzyme was detected in leukemic cells of 5 patients with acute lymphoblastic leukemia and 1 patient with chronic myelogenous leukemia, whereas 16 patients with different forms of leukemia or lymphoma were negative for this enzyme. Comparative studies using a biochemical and an indirect immunofluorescence assay revealed complete concordance between these three methods.

Topics:
dna nucleotidylexotransferase, leukemia, enzymes, lymphoma, acute lymphocytic leukemia, leukemia, myelocytic, chronic, leukemic cells, peroxidase, fluorescent antibody technique, indirect, leukocytes
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Copyright © 1981 by The American Society of Hematology
1981
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