Linkage analysis was performed on a large pedigree with an autosomal dominant platelet disorder and a striking propensity in affected family members to develop hematologic malignancy, predominantly acute myelogenous leukemia. We report the linkage of the autosomal dominant platelet disorder to markers on chromosome 21q22. Four genetic markers completely cosegregate with the trait and yield maximum logarithm of difference scores ranging from 4.9 to 10.5 (theta = .001). Two flanking markers, D21S1265 and D21S167, define a critical region for the disease locus of 15.2 centimorgan. Further analysis of this locus may identify a gene product that affects platelet production and function and contributes to the molecular evolution of hematologic malignancy.
ARTICLES|
June 15, 1996
Linkage of a familial platelet disorder with a propensity to develop myeloid malignancies to human chromosome 21q22.1-22.2
CY Ho,
CY Ho
Department of Medicine, Division of Hematology/Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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B Otterud,
B Otterud
Department of Medicine, Division of Hematology/Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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RD Legare,
RD Legare
Department of Medicine, Division of Hematology/Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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T Varvil,
T Varvil
Department of Medicine, Division of Hematology/Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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R Saxena,
R Saxena
Department of Medicine, Division of Hematology/Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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DB DeHart,
DB DeHart
Department of Medicine, Division of Hematology/Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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SE Kohler,
SE Kohler
Department of Medicine, Division of Hematology/Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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JC Aster,
JC Aster
Department of Medicine, Division of Hematology/Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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SB Dowton,
SB Dowton
Department of Medicine, Division of Hematology/Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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FP Li,
FP Li
Department of Medicine, Division of Hematology/Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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M Leppert,
M Leppert
Department of Medicine, Division of Hematology/Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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DG Gilliland
DG Gilliland
Department of Medicine, Division of Hematology/Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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Blood (1996) 87 (12): 5218–5224.
Citation
CY Ho, B Otterud, RD Legare, T Varvil, R Saxena, DB DeHart, SE Kohler, JC Aster, SB Dowton, FP Li, M Leppert, DG Gilliland; Linkage of a familial platelet disorder with a propensity to develop myeloid malignancies to human chromosome 21q22.1-22.2. Blood 1996; 87 (12): 5218–5224. doi: https://doi.org/10.1182/blood.V87.12.5218.bloodjournal87125218
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