1. The cases of four Negro patients with splenomegaly and targeting of the red cells are reported.

2. Electrophoretic analysis of the hemoglobin in these cases revealed type C hemoglobin exclusively.

3. An analysis of the genetic, clinical, and hematologic manifestations was made.

4. For convenience, the name hemoglobin C disease has been given to the mild hemolytic syndrome observed in these patients.

5. Electrophoretic recognition of hemoglobin C by filter paper and Tiselius technics is illustrated.

6. Differential diagnosis is discussed with special attention directed to the mild form of Mediterranean anemia.

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© 1955 by American Society of Hematology, Inc.
1955
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