Multiple Myelomatosis Treated with a Combination of Urethane and an Oral Nitrogen Mustard

1. 17 Cases of advanced multiple myelomatosis have been treated with combined chemotherapy using small doses of urethane and an oral preparation of nitrogen mustard.

2. The object of such therapy was to test the hypothesis that a synergistic action existed between these compounds.

3. The results indicate that significant palliation was obtained in many patients treated and that in some the progress of the disease was modified.

4. In the dosage employed such combined therapy appears to be free from undesirable toxic manifestations and suitable for out-patient administration over long periods.