1. Thrombelastographic determinations were made in cases of AHG-, PTC- and PTA-deficiencies, in thrombocytopenias and in normal plasmas after the addition, in vitro, of heparin and synthetic heparin-like substances.

2. The components of the thrombelastogram (TEG) were correlated with respect to the reaction time (r), the rate of clot formations (k), and the maximal amplitude (ma).

3. The differentiation of the hemophilic and thrombocytopenic syndromes was made on the basis of the typical variations of r, k and ma: prolonged r and k in hemophilia, prolonged k and decreased ma in thrombocytopenias.

4. The behavior of heparinized blood was characterized by a hemophilia-like prolongation of r and k and a thrombocytopenic-like decrease of ma, with variations depending on the compound used.

5. The correlations between the r, k and ma values of TEG are suggested for the evaluation of thrombelastography.

Topics:
factor xi deficiency, hemophilia a, hemophilias, heparin, plasma, reaction time, thrombelastography, thrombocytopenia
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© 1956 by American Society of Hematology, Inc.
1956
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