Abstract 4596

Background:

Localized Laryngeal Amyloidosis (LA) is a rare condition. There is limited understanding of its natural history. Our aim is to report the clinical evolution of a patient diagnosed with localized LA.

Methods:

Case report.

Results:

In May 2002, a 43-year-old gentleman presented with hoarseness and a CT scan of the neck showed a thickening of the right vocal cord with a mass that measured 2.9 × 1.2 cm in widest diameter. The patient had this mass removed surgically and the pathology showed a positive Congo red staining and a positive birefringence under polarized light, diagnostic of amyloidosis. No evidence of systemic amyloidosis or an overt B-cell lymphoma was found in this patient.

Patient lost follow-up until October 2008 when he was found to have soft tissue induration around the left false vocal cord area. The biopsy showed again amyloidosis.

Conclusions:

LA recurrences can manifest several years after initial diagnosis. Long-term follow-up is essential.

Disclosures:

No relevant conflicts of interest to declare.

Topics:
amyloidosis, larynx, follow-up, amyloidosis, systemic, biopsy, computed tomography, congo red, hoarseness, lymphoma, surgical procedures, operative

Author notes

*

Asterisk with author names denotes non-ASH members.

© 2011 by The American Society of Hematology
2011
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