Abstract SCI-22

Imbalances of iron homeostasis account for some of the most common human diseases. Pathologies can result from both iron deficiency or overload. The hepcidin/ferroportin and the IRE/IRP regulatory systems balance systemic and cellular iron metabolism, respectively, and understanding their points of intersection and crosstalk represents a major challenge in iron biology. I will discuss an emerging picture from studies with different mutant mouse lines according to which the “cellular” IRE/IRP system determines “set points” via its targets (including ferroportin and HIF2α). These are then subject to modulation via hepcidin in response to systemic cues.

Disclosures:

No relevant conflicts of interest to declare.

Topics:
iron, iron metabolism, regulatory protein, erythropoiesis, ferroportin, hepcidin, iron deficiency, spinal cord injuries

(1)

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(2)

Muckenthaler, MU, Galy, B, Hentze, MW. Systemic iron homeostasis and the IRE/IRP regulatory network. Ann Rev Nutr. 2008;28:197–213.

(3)

Galy, B, Ferring-Appel, D, Sauer, S, Kaden, S, Puy, H, Lyoumi, S, Kölker, S, Gröne, H-J, Hentze, MW. Iron regulatory proteins secure mitochondrial iron homeostasis and function. Cell Metab. 2010;12:194–201.

(4)

Hentze, MW, Muckenthaler, MU, Galy, B, Camaschella, C. Two to tango: Regulation of mammalian iron metabolism. Cell. 2010;142:24–38.

Author notes

*

Asterisk with author names denotes non-ASH members.

© 2011 by The American Society of Hematology
2011
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