On page 1475, there are errors in the assembly of Figure 5C. The pGSK blot was misplaced with respect to its tubulin loading control. The pGSK blot is now appropriately associated with the tubulin blot from the same experiment, which also includes the pFAK blot. The corresponding author has provided original images and evidence consistent with her attestation that all images are from the same experiment. Also, in the description of Figure 5C in the figure legend, the GMI-1070 concentration, "500mM," should read "250 or 500 μM." The corrected Figure 5C and legend are shown below.
Interaction of PSGL-1 and P-selectin regulates adhesion-related signaling and β-integrin activation in MM cells. (C) HUVECs were treated with or without GMI-1070 (250 or 500 μM for 1 hour), nontreated MM1s cells were cocultured with the HUVECs for 1 hour, and MM1s cells not cocultured with HUVECs served as a control. MM cells were then separated from the HUVECs, lysed, and whole-cell lysates were subjected to Western blotting for pFAK, pAKT, pCoffilin, pSRC, and p-GSK3α/β. Coculture of MM cells with HUVECs induced adhesion-related signaling in MM cells that was reversed by GMI-1070.
Interaction of PSGL-1 and P-selectin regulates adhesion-related signaling and β-integrin activation in MM cells. (C) HUVECs were treated with or without GMI-1070 (250 or 500 μM for 1 hour), nontreated MM1s cells were cocultured with the HUVECs for 1 hour, and MM1s cells not cocultured with HUVECs served as a control. MM cells were then separated from the HUVECs, lysed, and whole-cell lysates were subjected to Western blotting for pFAK, pAKT, pCoffilin, pSRC, and p-GSK3α/β. Coculture of MM cells with HUVECs induced adhesion-related signaling in MM cells that was reversed by GMI-1070.
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