Abstract

A reciprocal t(3;8) BCL6::MYC fusion is common in large B-cell lymphoma (LBCL) with MYC and BCL6 disruption. These pseudo–double-hit cases are not adverse, whereas t(3;8)MYC/BCL6 lymphoma has an inferior prognosis relative to other MYC-rearranged LBCL.

1.
Copie-Bergman
C
,
Cuillière-Dartigues
P
,
Baia
M
, et al
.
MYC-IG rearrangements are negative predictors of survival in DLBCL patients treated with immunochemotherapy: a GELA/LYSA study
.
Blood
.
2015
;
126
(
22
):
2466
-
2474
.
2.
Rosenwald
A
,
Bens
S
,
Advani
R
, et al
.
Prognostic significance of MYC rearrangement and translocation partner in diffuse large B-cell lymphoma: a study by the Lunenburg lymphoma biomarker consortium
.
J Clin Oncol
.
2019
;
37
(
35
):
3359
-
3368
.
3.
Li
S
,
Wang
Z
,
Lin
L
, et al
.
BCL6 rearrangement indicates poor prognosis in diffuse large B-cell lymphoma patients: a meta-analysis of cohort studies
.
J Cancer
.
2019
;
10
(
2
):
530
-
538
.
4.
El-Sharkawi
D
,
Sud
A
,
Prodger
C
, et al
.
A retrospective study of MYC rearranged diffuse large B-cell lymphoma in the context of the new WHO and ICC classifications
.
Blood Cancer J
.
2023
;
13
(
1
):
54
.
5.
Khurana
A
,
Mwangi
R
,
Cerhan
JR
, et al
.
Comparing clinical characteristics and outcomes of MYC and BCL6 double hit lymphoma (DHL- BCL6) with other aggressive B-cell lymphomas: understanding the impact of new WHO and International Consensus Classifications [abstract]
.
Blood
.
2023
;
142
(
suppl 1
):
67
.
6.
Alaggio
R
,
Amador
C
,
Anagnostopoulos
I
, et al
.
The 5th edition of the World Health Organization classification of haematolymphoid tumours: lymphoid neoplasms
.
Leukemia
.
2022
;
36
(
7
):
1720
-
1748
.
7.
Campo
E
,
Jaffe
ES
,
Cook
JR
, et al
.
The international consensus classification of mature lymphoid neoplasms: a report from the Clinical Advisory Committee
.
Blood
.
2022
;
140
(
11
):
1229
-
1253
.
8.
Sandlund
JT
,
Kastan
MB
,
Kennedy
W
, et al
.
A subtle t(3;8) results in plausible juxtaposition of MYC and BCL6 in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia
.
Cancer Genet Cytogenet
.
2006
;
168
(
1
):
69
-
72
.
9.
Chong
LC
,
Ben-Neriah
S
,
Slack
GW
, et al
.
High-resolution architecture and partner genes of MYC rearrangements in lymphoma with DLBCL morphology
.
Blood Adv
.
2018
;
2
(
20
):
2755
-
2765
.
10.
Zhang
C
,
Stelloo
E
,
Barrans
S
, et al
.
Non-IG::MYC in diffuse large B-cell lymphoma confers variable genomic configurations and MYC transactivation potential
.
Leukemia
.
2024
;
38
(
3
):
621
-
629
.
11.
Ryan
RJH
,
Drier
Y
,
Whitton
H
, et al
.
Detection of enhancer-associated rearrangements reveals mechanisms of oncogene dysregulation in B-cell lymphoma
.
Cancer Discov
.
2015
;
5
(
10
):
1058
-
1071
.
12.
Ohno
H
,
Nakagawa
M
,
Kishimori
C
,
Fukutsuka
K
,
Honjo
G
.
Cryptic t(3;8)(q27;q24) and/or MYC-BCL6 linkage associated with MYC expression by immunohistochemistry is frequent in multiple-hit B-cell lymphomas
.
Blood Cancer J
.
2017
;
7
(
6
):
e578
.
13.
Wright
GW
,
Huang
DW
,
Phelan
JD
, et al
.
A probabilistic classification tool for genetic subtypes of diffuse large B cell lymphoma with therapeutic implications
.
Cancer Cell
.
2020
;
37
(
4
):
551
-
568.e14
.
14.
Bartlett
NL
,
Wilson
WH
,
Jung
S-H
, et al
.
Dose-adjusted EPOCH-R compared with R-CHOP as frontline therapy for diffuse large B-cell lymphoma: clinical outcomes of the phase III Intergroup Trial Alliance/CALGB 50303
.
J Clin Oncol
.
2019
;
37
(
21
):
1790
-
1799
.
15.
Chaganti
S
,
Illidge
T
,
Barrington
S
, et al
.
Guidelines for the management of diffuse large B-cell lymphoma
.
Br J Haematol
.
2016
;
174
(
1
):
43
-
56
.
16.
McMillan
AK
,
Phillips
EH
,
Kirkwood
AA
, et al
.
Favourable outcomes for high-risk diffuse large B-cell lymphoma (IPI 3-5) treated with front-line R-CODOX-M/R-IVAC chemotherapy: results of a phase 2 UK NCRI trial
.
Ann Oncol
.
2020
;
31
(
9
):
1251
-
1259
.
17.
Lamb
M
,
Painter
D
,
Howell
D
, et al
.
Lymphoid blood cancers, incidence and survival 2005-2023: a report from the UK’s Haematological Malignancy Research Network
.
Cancer Epidemiol
.
2024
;
88
:
102513
.
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