Coagulation studies in a 22 year old Caucasian male have revealed the presence of combined deficiencies of PTA and AHG with vascular fragility. Members of his family have been shown to have isolated deficiencies of PTA, AHG, vascular fragility and various combinations of all three defects. The family studies indicating segregation of the PTA and AHG deficiencies lend support to the concept that these two are clinically separate entities.

The inheritance patterns of PTA deficiencies and AHG deficiencies with vascular fragility are discussed.

The problems encountered in this type of study are mentioned, and the precautions to be observed are indicated.

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© 1960 by American Society of Hematology, Inc.
1960
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