Vitamin E Deficiency in the Monkey. IV. Further Studies of the Anemia with Emphasis on Bone Marrow Morphology

Nuclear abnormalities were observed in all the erythroid precursors in the bone marrow of vitamin E-deficient monkeys. Many of these cells were multinucleated. The remainder of the marrow elements appeared normal. Reasons for considering the anemia to be primarily due to inadequate erythropoiesis are given.

Serum iron, glutathione stability of the erythrocytes, hemoglobin electrophoresis, osmotic fragilities and platelet counts were all found to be normal in the vitamin E-deficient monkey.