Blood Coagulation and Vascular Integrity: Effects of Heparin

The administration of large and repeated doses of heparin to normal rats resulted in increased output of red blood cells into the lymph, comparable to that associated with x-ray induced thrombocytopenia. A considerable lapse of time was observed between the inhibition of blood coagulation and the increase of vascular permeability to red blood cells. The latter was not decreased by return of the blood clotting to normal.