Methods of Altering Nitrogen Mustard Toxicity in Dogs. I. Spleen and Mesenteric Artery Exclusion

Forty-five dogs have been treated with varying dosages of nitrogen mustard. Nineteen of these dogs were subjected to cross-clamping of the splenic vessels prior to administration of the drug. No appreciable improvement in mortality or degree of marrow depression has been found with this technic.

Exclusion of the spleen and small intestine has been found to be a practical and reliable method for protecting these organs from the effect of intravenous administration of nitrogen mustard.