1) Six patients have been presented who, subsequent to long-standing hyperthyroidism, developed a lymphoma (one lymphoblastic lymphosarcoma, one Hodgkin’s disease, one giant follicular lymphoma, and three lymphocytic lymphosarcoma or leukemia).

2) Experimental evidence suggests that hyperthyroidism stimulates and hypothyroidism inhibits lymphoid structures, and hyperthyroidism promotes tumor growth in animals. The mechanism of this action is not clear.

3) Three additional cases of hyperthyroidism followed by the development of a lymphoma were found in the literature.

4) It is suggested that prolonged hyperthyroidism may be a contributory factor in the development of lymphomas or allied disorders in man.

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© 1963 by American Society of Hematology, Inc.
1963
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