The First Observation of Homozygous Hemoglobin S-Alpha Thalassemia Disease and Two Types of Sickle Cell Thalassemia Disease: (a) Sickle Cell-Alpha Thalassemia Disease, (b) Sickle Cell-Beta Thalassemia Disease

Six patients with sickle cell-thalassemia disease are reported together with hematologic and genetic data. A case of homozygous hemoglobin S-alpha thalassemia disease, the son of parents with asymptomatic sickle cell-thalassemia disease and sickle cell trait, is presented, showing the possibilities involved in the presence of two genes for hemoglobin S and one gene for thalassemia.