The Course of Experimentally Induced Hemolytic Anemia in a Primaquine-Sensitive Caucasian : A Case Study

Two severe hemolytic crises, in a month’s period, were induced by primaquine in a glucose-6-phosphate dehydrogenase deficient Sardinian male.

Young red blood cells tagged with Fe⁵⁹ 10 to 16 days earlier were destroyed in the second hemolytic episode.

The implications of these experiments on the nature of drug-induced hemolysis in Caucasians are briefly discussed.