Circulating lymphocytes were isolated from normal individuals and from patients with IM. IM lymphocytes synthesized RNA at 10 times the rate of normal lymphocytes. A 1-hour exposure to PHA did not result in the stimulation of 4 to 30S RNA synthesis which occurs in a similarly treated normal lymphocyte. RNA synthesis in IM lymphocytes actually appeared to be depressed by this short exposure to PHA.

Topics:
infectious mononucleosis, lymphocytes, phytohemagglutinins, rna, rna chemical synthesis, depressive disorders, depressed mood
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© 1966 by American Society of Hematology, Inc.
1966
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