Induction of Autoimmune Hemolytic Disease by Diffusible Substances from the Thymus of NZB/Bl Mice

Mice of four strains were thymectomized neonatally and implanted with Millipore diffusion chambers containing thymic tissue from newborn mice of the NZB/Bl strain. Of a total of 60 surviving animals, 50 developed a positive Coombs’ test and other evidences of autoimmune hemolytic disease. Controls remained negative.

Various possibilities concerning the nature of the membrane-passing factor or agent are considered.