The Ultrastructure of an Abnormal Cell in Sézary’s Syndrome

Sézary described a characteristic cell found in a syndrome which bears his name. This syndrome is manifested by erythroderma, lymphadenopathy, and abnormal circulating cells. The electron microscope was used to study skin, lymph nodes, and blood from three Sézary patients and all demonstrated characteristic cells. The nucleus of this Sézary cell was strikingly irregular, indented, lobulated, and serpentine, often narrowed to a single row of nuclear particles. The cytoplasm exhibited no abnormalities. No abnormal cells similar to those described have been found in any control tissues studied.