Hemoglobin D Los Angeles in Two Caucasian Families: Hemoglobin SD Disease and Hemoglobin D Thalassemia

Data are presented on two Caucasian families with hemoglobin D Los Angeles, (α₂β₂^121gln) In one family, the mother, of Spanish origin, has sickle cell trait and the father, of Mexican origin, has hemoglobin D trait. One child has sickle cell hemoglobin D disease and suffers from a moderately severe hemolytic anemia. In the other family, of English, Scotch, and Irish ancestry, one member has the hemoglobin DAF pattern of hemoglobin D β-thalassemia disease and suffers from moderate hemolytic disease.