Brief Report: A Cytogenetic Study of Acute Erythroleukemia in Children

Three children with acute erythroleukemia were studied for chromosomal changes. Two of them had persistently normal karyotypes despite relapse. The third patient was missing a C chromosome, and had 45/46 mosaicism in the bone marrow and a dichotomy between blood (mode of 46) and bone marrow (mode of 45). All of these abnormalities were only evident when he was in relapse. Following partial remission induced with cytosine arabinoside, all subsequent analyses were normal. This is the third case reported of a child with erythroleukemia with aneuploidy in the C group of the chromosomes.