Brief Report: Plasma Activity of Antihemophilic Globulin (AHG) and Other Coagulation Factors in Swiss Type of Agammaglobulinemia

Although the site of synthesis and storage of antihemophilic globulin (AHG, Factor VIII) is unknown, available evidence suggests that these processes occur in the reticuloendothelial system. We studied the plasma activity of AHG and other coagulation factors in a patient with Swiss type of agammaglobulinemia. Except for increased fibrinogen concentration probably related to chronic infection, the activity of all coagulation factors including AHG was within the normal range. These studies suggest that the lymphocyte and plasma cell are unlikely sites of AHG synthesis or storage.