Studies on the Regulation of Granulopoiesis. I. The Response to Neutropenia

Mice were irradiated with one leg shielded in order to study the response of the protected marrow to neutropenia. The findings suggested that neutropenia increases the rate of release of segmented neutrophils from the marrow and also increases the rate of production of neutrophil precursors, possibly by increasing the rate of flux from a committed granulocytic stem cell compartment into the myeloblast-promyelocyte compartment. A humoral mechanism may be involved.