The interaction between leukocyte antigens and specific antibodies can cause lysis of the red cells of paroxysmal nocturnal hemoglobinuria (PNH) in vitro. It is suggested that the activation of complement ensuing from the antigen-antibody interaction is responsible for PNH cell lysis. The clinical implications of this finding are briefly outlined.

Topics:
cytolysis, erythrocytes, leukocytes, paroxysmal nocturnal hemoglobinuria, antigen-antibody reactions, antibodies, antigens, complement system proteins, human leukocyte antigens
This content is only available as a PDF.
© 1970 by American Society of Hematology, Inc.
1970
Sign in via your Institution