Surface Morphology of Human Leukocytes

Surface morphology of individual leukocytes was correlated with their light microscopic appearance by a simple, direct technique. Circulating leukocytes of all types were roughened spheres with diameters similar to red cells, and leukocyte types could not be distinguished consistently by surface morphology. After surface contact, leukocytes increased in diameter and exhibited a variety of projections. Cells spread on surfaces could be identified by external morphology. Several stages in the phagocytosis of latex particles were demonstrated. The study of surface contours by scanning electron microscopy represents a new approach to morphology.