COMPARISON OF VITAMIN B₁₂ FROM LIVER AND FROM STREPTOMYCES GRISEUS IN THE TREATMENT OF PERNICIOUS ANEMIA

1. A clinical remission in one case of pernicious anemia in relapse treated with 50 µg. of vitamin B₁₂ from liver is reported; the patient was followed for 114 days after two doses of 25 µg. were given on successive days and a peak of 3,900,000 erythrocytes occurred on the eighty-sixth day.

2. Preliminary observations are reported in 2 patients with pernicious anemia in relapse treated with a vitamin B₁₂ derived from Streptomyces griseus; the first patient who had no neurologic complaints received 32 µg. while the second was given two doses of 32 µg. each because of severe, subacute, combined degeneration. A good hematologic response and a satisfactory clinical remission occurred in both cases. There was definite improvement neurologically in the second case.

3. The administration of 32 µg. of vitamin B₁₂ derived from Streptomyces griseus to each of 5 cases of pernicious anemia in remission resulted in minor subjective and objective improvement.