Expression and Linkage of Genes for X-linked Hemophilias A and B in the Dog

In the article "Expression and Linkage of Genes for X-linked Hemophilias A and B in the Dog" by Brinkhous et al. (Blood, Vol. 41, No. 4, April 1973, pp. 577-585) the following items should read as given below:

Page 579, paragraph 3, Results

Once doubly heterozygous adult females were available, they were bred to determine the recombination frequency among the progeny. The sires were of the three phenotypes: normal, hemophilia A, and hemophilia B. The results from 15 litters, with 78 tested progeny, are shown in Table 2. The male:female ratio was 33:45 (x² = 2.45; p > 0.10). From these matings, four male genotypes are possible, and all were observed. The crossover ratio was 15:18 in males, suggesting a deficiency of doubly hemophilic males (^aX_bY) from the XY · ^aXX_b and ^aXY · ^aXX_b matings.

Page 579, paragraph 5, Results

The ratio of crossovers to noncrossovers for all progeny, both male and females, of the double heterozygotes is 41:37. This is so close to the maximum 50% frequency of 39:39 that the linkage distance is too great to be measured.

Page 580, Table 2, line 4, Genotype of Noncrossover Females, should read ^aXX_b.

Page 584, first paragraph at top of page, the last sentence is:

These data thus suggest that X-inactivation was indeed random, without respect to the paternal or maternal source of the X-chromosome.