During a 5-yr leukemia surveillance study in the metropolitan Kansas City area, four patients who had previously received irradiation therapy for carcinoma of the larynx developed acute leukemia. The frequency of occurrence represents a significant increase of the observed over the expected. These findings indicate that, even with such localized radiotherapy, the possibility of irradiation-induced leukemia must be considered in therapeutic decisions.

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© 1974 by American Society of Hematology, Inc.
1974
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