In six normal subjects, no surface immunoglobulins were detected on blood lymphocytes containing bundle-shaped tubular (BST) inclusions, after incubation with anti-human IgM peroxidase-labeled Fab'2 fragments. These Fab'2 fragments from pepsin-digested sheep anti-human immunoglobulins revealed human mu kappa, and lambda chains. These results suggest that the BST inclusions do not belong to B lymphocytes but belong to T cells and/or a third lymphocyte population, including K cells and precursors of T and B cells.

Topics:
immunoglobulin m, immunoglobulins, lymphocytes, pepsin a, peroxidase, receptors, antigen, b-cell, b-lymphocytes, natural killer cells, sheep, t-lymphocytes
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Copyright © 1980 by The American Society of Hematology
1980
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