1. A series of 212 cases of acute leukemia classified according sex and age is presented. Fifty-eight out of 212 were diagnosed by means of phase contrast microscopy.

2. In addition to this personal series, other series collected from the literature tile reviewed. These include both acute and chronic leukemia.

3. The thorough analysis of maximal frequency of the disease according to age, shows that there is, in the course of life, an inverse relation between lymphoid and myeloid leukemias as to the period of life in which they appear. This relation favors the view that a particular ratio of equilibrium must exist between the two systems: lymphoid and myeloid.

4. It is suggested that such an equilibrium might depend upon endocrine factors.

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© 1951 by American Society of Hematology, Inc.
1951
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